One-pot synthesis and antiproliferative evaluation of pyrazolo[3,4-d]pyrimidine derivatives
β Scribed by Yu-Ying Huang; Li-Ya Wang; Chun-Hsi Chang; Yueh-Hsiung Kuo; Kimiyoshi Kaneko; Hiroyuki Takayama; Masayuki Kimura; Shin-Hun Juang; Fung Fuh Wong
- Book ID
- 119375779
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 254 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0040-4020
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## Abstract Pyrazoloβ[3,4β__d__]pyrimidineβ4,6βdiones **5** and pyrazolo[4,3β__d__]pyrimidineβ5,7βdiones **7** were synthesized by Curtius rearrangement of pyrazolic monoβesters **2** and **3** followed by heteroβcyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.