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Pyrimidine derivatives and related compounds. A novel synthesis of pyrimidines, pyrazolo[4,3-d]pyrimidines and isoxazolo[4,3-d] pyrimidine

✍ Scribed by Mohamed Hilmy Elnagdi; Shereif Mahmoud Fahmy; Ebtisam Abdel Aziz Hafez; Mohamed Riffaat Hamza Elmoghayar; Samir Abdel Rahman Amer

Book ID
112125766
Publisher
Journal of Heterocyclic Chemistry
Year
1979
Tongue
English
Weight
215 KB
Volume
16
Category
Article
ISSN
0022-152X

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## Abstract magnified image A number of derivatives of isoxazolo[4,3‐__d__]pyrimidine and isoxazolo[4,5‐__d__]pyrimidine were prepared with potential anticancer activity. Condensation of 4‐amino‐5‐benzoyl‐isoxazolo‐3‐carboxylic acid hydrazide with ethyl orthoformate and then with different amines

A convenient synthesis of pyrazolo[3,4-d
A convenient synthesis of pyrazolo[3,4-d]pyrimidine-4,6-dione and pyrazolo[4,3-d]pyrimidine-5,7-dione derivatives
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## Abstract Pyrazolo‐[3,4‐__d__]pyrimidine‐4,6‐diones **5** and pyrazolo[4,3‐__d__]pyrimidine‐5,7‐diones **7** were synthesized by Curtius rearrangement of pyrazolic mono‐esters **2** and **3** followed by hetero‐cyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.