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Synthesis and pharmacological screening of derivatives of isoxazolo[4,3-d]pyrimidine and isoxazolo[4,5-d]pyrimidine

✍ Scribed by Edwin Wagner; Kamal Al-Kadasi; Lilianna Becan; Wanda Sawka-Dobrowolska

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
123 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A number of derivatives of isoxazolo[4,3‐d]pyrimidine and isoxazolo[4,5‐d]pyrimidine were prepared with potential anticancer activity. Condensation of 4‐amino‐5‐benzoyl‐isoxazolo‐3‐carboxylic acid hydrazide with ethyl orthoformate and then with different amines gave a series of 3‐benzoyl‐7‐oxo‐7__H__‐isoxazolo[4,3‐d]pyrimidin‐6‐yl‐aryliden‐formamidine. A series of 5‐aminomethyl‐7‐phenyl‐isoxazolo[4,5‐d]pyrimidine‐3‐carboxamide was obtained from 4‐amino‐5‐benzoylisoxazole‐3‐carboxamide with acetonitrile, and chloroacetonitrile with gaseous hydrogen chloride. Some of these compounds were tested for their cytotoxic activity. J. Heterocyclic Chem., (2010).

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