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Synthesis and Substrate Properties of Modified Nucleoside 5"-Triphosphates Mimicking dATP in the Reactions of DNA Synthesis Catalyzed by DNA Polymerases

โœ Scribed by Yu. A. Sharkin; D. G. Semizarov; L. S. Viktorova; M. K. Kukhanova


Book ID
110312112
Publisher
SP MAIK Nauka/Interperiodica
Year
2001
Tongue
English
Weight
113 KB
Volume
27
Category
Article
ISSN
1068-1620

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Modified triphosphates of carbocyclic nu
โœ Natalya Dyatkina; Elena Shirokova; Fritz Theil; Stanley M. Roberts; Alexander Kr ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 204 KB

New triphosphate derivatives of carbocyclic nucleoside analogues have been synthesized and shown to be potent substrates for terminal deoxynucleotidyltransferase and/or HIV reverse transcriptase; the compounds are stable to dephosphorylation with human placental alkaline phosphatase.