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New modified nucleoside 5′-triphosphates: synthesis, properties towards DNA polymerases, stability in blood serum and antiviral activity

✍ Scribed by Shipitsin, Alexander V.; Victorova, Lyubov S.; Shirokova, Elena A.; Dyatkina, Natalya B.; Goryunova, Lyudmila E.; Beabealashvilli, Robert Sh.; Hamilton, Chris J.; Roberts, Stanley M.; Krayevsky, Alexander


Book ID
111962952
Publisher
Royal Society of Chemistry
Year
1999
Weight
361 KB
Volume
8
Category
Article
ISSN
1472-7781

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Modified triphosphates of carbocyclic nu
✍ Natalya Dyatkina; Elena Shirokova; Fritz Theil; Stanley M. Roberts; Alexander Kr 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 204 KB

New triphosphate derivatives of carbocyclic nucleoside analogues have been synthesized and shown to be potent substrates for terminal deoxynucleotidyltransferase and/or HIV reverse transcriptase; the compounds are stable to dephosphorylation with human placental alkaline phosphatase.