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Synthesis and Stability of Functionalized Epoxides Topologically Related to β-Lactam Antibiotics

✍ Scribed by Jacqueline Marchand-Brynaert; Didier Ferroud; Béatrice Serckx-Poncin; Léon Ghosez


Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
576 KB
Volume
99
Category
Article
ISSN
0037-9646

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The stereoselective synthesis of two precursors of tricyclic β-ring-forming reaction followed by the reduction of a functionalized aromatic substituent at C-4 of the β-lactam lactam antibiotics (trinems) has been attempted by a novel approach that involves a highly stereoselective azetidinone nucleu