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A Novel Approach to the Synthesis of Precursors of Tricyclic β-Lactam Antibiotics

✍ Scribed by Rita Annunziata; Maurizio Benaglia; Mauro Cinquini; Franco Cozzi; Laura Poletti; Laura Raimondi; Alcide Perboni

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
296 KB
Volume
1999
Category
Article
ISSN
1434-193X

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✦ Synopsis

The stereoselective synthesis of two precursors of tricyclic β-ring-forming reaction followed by the reduction of a functionalized aromatic substituent at C-4 of the β-lactam lactam antibiotics (trinems) has been attempted by a novel approach that involves a highly stereoselective azetidinone nucleus.

trichlorotitanium enolate of 2-pyridylthioesters with im- [a] Centro C.N.R. and Dipartimento di Chimica Organica e Industriale, water in the presence of a catalytic amount of Pd(OAc)

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