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ChemInform Abstract: An Approach to the Synthesis of 5,5-trans-Fused Lactam Analogues of β-Lactam Antibiotics.

✍ Scribed by Paul W. Smith; Andrew R. Whittington; Kevin N. Cobley; Albert Jaxa-Chamiec; Harry Finch

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
32
Category
Article
ISSN
0931-7597

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The stereoselective synthesis of two precursors of tricyclic β-ring-forming reaction followed by the reduction of a functionalized aromatic substituent at C-4 of the β-lactam lactam antibiotics (trinems) has been attempted by a novel approach that involves a highly stereoselective azetidinone nucleu