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Synthesis and stability of [1,3-14C2]-glyceryl trinitrate

✍ Scribed by J. Szammer; E. Simon-Trompler; J. Máté; M. Abermann; I. Klebovich

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
205 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of [1,3‐^14^C~2~]‐glyceryl trinitrate (^14^C]‐GTN) labelled with quasi carrier free carbon‐14 atom in the 1,3‐positions of the molecule was effected in four reaction steps from ^14^CO~2~ (3,5 % overall yield). The chemical and radiochemical purity of [^14^C]‐GTN was found better than 99% controlled by HPLC‐Radioactivity Monitor and TLC‐Digital Autoradiograph methods. Study of the radiochemical stability in dilute solution at 5 °C shows that the product can be stored at least for a month without detectable decomposition.

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