✦ LIBER ✦

Synthesis and spectral properties of 5-methylthio-4H-1-(p-substituted-phenyl)-3a-(p-substituted-phenyl)-9-[(m-; and p-substituted)-phenoxy]-3a,4-dihydro[1,2,4]oxadiazolo[4,5-a][1,5]benzodiazepines

✍ Scribed by Eduardo CortÉS Cortés; Elide HernÁNdez Cruz; Olivia GarcÍA Mellado

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 309 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360224

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✦ Synopsis

Abstract

The preparation of eight novel substituted [1,2,4]oxadiazolo[4,5‐a][1,5]benzodiazepines which have potentially useful pharmacological properties; by 1,3‐cycloaddition of benzonitrile oxides, generated in situ from benzohydroxamoyl chloride and triethylamine, to 1,5‐benzodiazepine derivatives is described. The structure of all products was corroborated by ir, ^1^H‐nmr, ^13^C‐nmr and ms.

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