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Synthesis and spectral properties of 2-methylthio-3H-4-(para-substituted-phenyl)-7-[(o-, and p-substituted)-phenylthio]-1,5-benzodiazepines

✍ Scribed by Eduardo Cortés Cortés; María I. Becerra López; Yazmín M. Osornio Pichardo

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
297 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of twelve new 2‐methylthio‐3__H__‐4‐(p‐substituted phenyl)‐7‐[(o‐, and p‐substituted)phenylthio]‐1,5‐benzodiazepines, which have potentially useful pharmacological properties, has been synthesized by condensing the 3,3‐dimercapto‐1‐(para‐substituted‐phenyl)‐2‐propen‐1‐one with 3,4‐diamino phenyl‐R‐phenylthio ethers, and subsequently the 1__H__‐1,5‐benzodiazepine‐2‐thiones obtained were treated with sodium hydride and methyl iodide. The structure of all products was corroborated by ir, ^1^H‐nmr, ^13^C‐nmr and ms.

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