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Synthesis and spectral properties of 2-methylthio-3H-7-[(o-; m- and p-substituted)phenoxy]-4-(p-substituted-phenyl)-[1,5]benzodiazepines

✍ Scribed by Eduardo Cortés Cortés; Cristina A. Cortés Romero; Olivia García Mellado

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
35 KB
Volume
39
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of eleven new 2‐methylthio‐3__H__‐7‐[(o‐; m‐ and p‐substituted) phenoxy]‐4‐(p‐substituted‐phenyl)‐[1,5]benzodiazepines, which have potentially useful pharmacological activities, has been synthesized by condensing the 4‐[(o‐; m‐ and p‐R~1~)phenoxy]‐1,2‐phenylendiamines with 3,3‐dimercapto‐1‐(p‐R~2~‐phenyl)‐2‐propen‐1‐one. Afterward the l__H__‐[1,5]benzodiazepine‐2‐thiones obtained were treated with sodium hydride and methyl iodide. The structure of all products was corroborated by ir, ^1^H nmr, ^13^C nmr and ms.

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