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Synthesis and spectral properties of 2-[(o- and p-substituted)aminophenyl] -3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines

✍ Scribed by Eduardo Cortés Cortés; Raúl Salazar Franco; Olivia García Mellado


Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
84 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

A series of twelve new 2‐[(o‐ and p‐substituted)aminophenyl]‐3__H__‐5‐[(o‐ and p‐substituted)phenyl]‐7‐chloro‐1,4‐benzodiazepines, which have possible pharmacological properties has been obtained. The synthesis was carried out following six steps. The structure of all products was corroborated by ir, ^1^H nmr, ^13^C nmr and ms. In addition for the compound 2‐(o‐chloroaminophenyl)‐3__H__‐5‐(o‐fluorophenyl)‐7‐chloro‐1,4‐benzodiazepine 7, its structure was confirmed by X‐ray diffraction.


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