Synthesis and spectral properties of 2-[(o- and p-substituted)aminophenyl] -3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines
✍ Scribed by Eduardo Cortés Cortés; Raúl Salazar Franco; Olivia García Mellado
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2001
- Tongue
- English
- Weight
- 84 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A series of twelve new 2‐[(o‐ and p‐substituted)aminophenyl]‐3__H__‐5‐[(o‐ and p‐substituted)phenyl]‐7‐chloro‐1,4‐benzodiazepines, which have possible pharmacological properties has been obtained. The synthesis was carried out following six steps. The structure of all products was corroborated by ir, ^1^H nmr, ^13^C nmr and ms. In addition for the compound 2‐(o‐chloroaminophenyl)‐3__H__‐5‐(o‐fluorophenyl)‐7‐chloro‐1,4‐benzodiazepine 7, its structure was confirmed by X‐ray diffraction.
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## Abstract A series of eleven new 2‐methylthio‐3__H__‐7‐[(__o__‐; __m__‐ and __p__‐substituted) phenoxy]‐4‐(__p__‐substituted‐phenyl)‐[1,5]benzodiazepines, which have potentially useful pharmacological activities, has been synthesized by condensing the 4‐[(__o__‐; __m__‐ and __p__‐R~1~)phenoxy]‐1,
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