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Synthesis and spectral determination of new derivatives of 1-[(p-substituted)phenyl]-3a-[(o- and p-substituted)phenyl]-5-chloro-9-methylthio-10,3a-dihydro-[1,2,4]-oxadiazolo[2,3-b][1,4]benzodiazepines

✍ Scribed by Eduardo Cortés; Erik Peréz Ramírez; Olivia García-Mellado de Cortés

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
248 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

  1. Lawesson reagent 2. NaH / CH 3 I 1. Triethylamine 2. Benzohydroxamoyl chloride derivates (N 2 )

A new synthesis to obtain eight novel derivatives of 1-[(p-substituted)phenyl]-3a-[(o-and p-substituted

]benzodiazepines with possible biological and pharmacological activity as anxiolytics, hypnotics, anticonvulsants in the central nervous system. The final products were obtained by condensation between 2-methylthio-5-[(o-; p-substituted)phenyl]-3H-7-chloro-[1,4]benzodiazepine with benzonitrile oxide generated in situ from benzohydroxamoyl chloride in triethylamine. The structure of all products was corroborated by ir, 1 H-nmr, 13 C-nmr, with experiments bidimensional and ms in low and high resolution.

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