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Synthesis and Sar of bulky 1-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists

โœ Scribed by H. Tecle; D.J. Lauffer; T. Mirzadegan; W.H. Moos; D.W. Moreland; M.R. Pavia; R.D. Schwarz; R.E. Davis


Book ID
118346089
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
383 KB
Volume
52
Category
Article
ISSN
0024-3205

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Synthesis and muscarinic M3 pharmacologi
โœ Ralf Plate; Marc J.M. Plaum; Thijs de Boer; John S. Andrews ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 634 KB

A series of 1-azabicyclo[2.2.2]octan-3-one oximes and related 1-azabicyclo-[2.2.2]-octan-3-one hydroxylamines were synthesized and tested for muscarinic M3 activity. All compounds showed at least some muscarinic binding properties, however, only one member of the series demonstrated mucarinic M3 ago