Synthesis of the selective muscarinic agonist (3R)-3-(6-chloropyrazin-2-yl)-1-azabicyclo [2.2.2] octane
β Scribed by Ashwood, Michael S.; Gibson, Andrew W.; Houghton, Peter G.; Humphrey, Guy R.; Roberts, D. Craig; Wright, Stanley H. B.
- Book ID
- 118235316
- Publisher
- Royal Society of Chemistry
- Year
- 1995
- Weight
- 528 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1472-7781
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A series of 1-azabicyclo[2.2.2]octan-3-one oximes and related 1-azabicyclo-[2.2.2]-octan-3-one hydroxylamines were synthesized and tested for muscarinic M3 activity. All compounds showed at least some muscarinic binding properties, however, only one member of the series demonstrated mucarinic M3 ago