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Synthesis and characterization of all four isomers of the muscarinic agonist, 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]

✍ Scribed by Saunders, John; Showell, Graham A.; Baker, Raymond; Freedman, Stephen B.; Hill, David; McKnight, Alexander; Newberry, Nigel; Salamone, John D.; Hirshfield, Jordan; Springer, James P.


Book ID
119961127
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
948 KB
Volume
30
Category
Article
ISSN
0022-2623

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A series of 1-azabicyclo[2.2.2]octan-3-one oximes and related 1-azabicyclo-[2.2.2]-octan-3-one hydroxylamines were synthesized and tested for muscarinic M3 activity. All compounds showed at least some muscarinic binding properties, however, only one member of the series demonstrated mucarinic M3 ago