Synthesis and SAR of a new class of 1-azabicyclo[2.2.1 Jheptan3-one. 0-(3-mtthyl-5-aryl-2-penten-4-ynyl) oxime muscarinic agonists are described Depend@ on the geometry of the C=N and C=C bonds, subnanomolar potency and/or high efbcy an achkved.
Z-(±)-1-azabicyclo[2.2.1]heptan-3-one, O-(3-aryl-2-propynyl) oximes as potential m1-subtype selective muscarinic agonists
✍ Scribed by H. Tecle; J.C. Jaen; C. Augelli-Szafran; S.D. Barrett; B.W. Caprathe; D.J. Lauffer; T. Mirzadegan; W.H. Moos; D.W. Moreland; M.R. Pavia; R.D. Schwarz; A.J. Thomas; R.E. Davis
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 298 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
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