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(±)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oximes: Potent muscarinic agonists

✍ Scribed by H. Tecle; D.J. Lauffer; R.E. Davis; T. Mirzadegan; D.W. Moreland; R.D. Schwan; A.J. Thomas; C. Raby; D. Eubanks; M.R. Brann; J.C. Jaen

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 279 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00087-a

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✦ Synopsis

Synthesis and SAR of a new class of 1-azabicyclo[2.2.1 Jheptan3-one. 0-(3-mtthyl-5-aryl-2-penten-4-ynyl) oxime muscarinic agonists are described Depend@ on the geometry of the C=N and C=C bonds, subnanomolar potency and/or high efbcy an achkved.

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