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ChemInform Abstract: Synthesis of Novel Succinamide Derivatives Having a 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M2 Muscarinic Receptor Antagonists. Part 2.

✍ Scribed by T. WATANABE; A. KAKEFUDA; I. KINOYAMA; K. TAKIZAWA; S. HIRANO; H. SHIBATA; I. YANAGISAWA

Publisher: John Wiley and Sons
Year: 2010
Weight: 36 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199811183

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✦ Synopsis

Synthesis of Novel Succinamide Derivatives Having a 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M 2 Muscarinic Receptor Antagonists. Part 2.

-Among the screened compounds derivative (IIIe) exhibits the highest affinity for M 2 muscarinic receptors and (IIId) shows the highest selectivity for M 2 over M 3

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