Synthesis and rapid purification of 32P-labeled photoactive analogs of farnesyl pyrophosphate
β Scribed by Tammy C. Turek; Igor Gaon; Mark D. Distefano
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 406 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2135
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π SIMILAR VOLUMES
Novel diphosphonate homologs 7a-7c, and their cyclic counterparts 8a-8c, of the previously synthesized farnesyl pyrophosphate analogs 1 and 2 were prepared and tested for their inhibition potency and specificity of the enzymes PFT and PGGT-I. Compound 2 was shown to be the most potent inhibitor of P
## Abstract Prenylated cysteine analogs, which mimic the prenylated cysteine residue of prenylated GTPβbinding proteins (Gβproteins), have been used in a variety of contexts for the study of prenylated Gβprotein behavior. In earlier work in this area, we prepared the photoactive analog [^35^S]**4**