✦ LIBER ✦

Farnesyl and geranylgeranyl pyrophosphate analogs incorporating benzoylbenzyl ethers: Synthesis and inhibition of yeast protein farnesyltransferase

✍ Scribed by Igor Gaon; Tammy C. Turek; Mark D. Distefano

Publisher: Elsevier Science
Year: 1996
Tongue: French
Weight: 349 KB
Volume: 37
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02066-7

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Farnesyl and Gerany

ChemInform Abstract: Farnesyl and Geranylgeranyl Pyrophosphate Analogues Incorporating Benzoylbenzyl Ethers: Synthesis and Inhibition of Yeast Protein Farnesyltransferase.

✍ I. GAON; T. C. TUREK; M. D. DISTEFANO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

Analogs of farnesyl pyrophosphate incorp

Analogs of farnesyl pyrophosphate incorporating internal benzoylbenzoate esters: Synthesis, inhibition kinetics and photoinactivation of yeast protein farnesyltransferase

✍ Tammy C. Turek; Igor Gaon; Mark D. Distefano 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 299 KB

Inhibitors of Protein:Farnesyl Transfera

Inhibitors of Protein:Farnesyl Transferase and Protein:Geranylgeranyl Transferase I: Synthesis of Homologous Diphosphonate Analogs of Isoprenylated Pyrophosphate

✍ Mark Overhand; Hanneke R. Stuivenberg; Elsbet Pieterman; Louis H. Cohen; Rick E. 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 297 KB

Novel diphosphonate homologs 7a-7c, and their cyclic counterparts 8a-8c, of the previously synthesized farnesyl pyrophosphate analogs 1 and 2 were prepared and tested for their inhibition potency and specificity of the enzymes PFT and PGGT-I. Compound 2 was shown to be the most potent inhibitor of P