Synthesis and radioligand activity of hydrogenated azepino[4,3-b]indoles
✍ Scribed by Mit’kin, O. D.; Ivachtchenko, A. V.; Frolov, E. B.; Tkachenko, S. E.; Kazey, V. I.; Okun’, I. M.
- Book ID
- 113077621
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 587 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0091-150X
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📜 SIMILAR VOLUMES
Monoor dibromo derivatives 2 and 3 were prepared by an efficient two-step route from 10-methyl-azepino [3,4-b]indole-1,5dione 1. Elimination reaction on 2 gave access to 4-bromo-10-methyl-2H,10H-azepino[3,4-b]indole-1,5-diones 4. Finally, 4-substituted 10methyl-2H,10H-azepino [3,4-b]indole-1,5-dione
## Abstract Cyclic β‐amino esters **4**, obtained from lactams, were condensed with indole‐2‐carbonyl chloride to afford the corresponding amides. Similarly, unusual conditions led to cyclisation at the 3‐position of the indole moiety in the presence of __p__TSA and ethylene glycol to afford previo