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Synthesis and quality control of 125I-and 14C-labelled 5-iodo-2′-deoxycytidine triphosphate

✍ Scribed by Ute Linz

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
261 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A method is described for a no‐carrier‐added synthesis and purification of doubly‐labelled [5‐^125^I, U‐^14^C]‐iododeoxycytidine triphosphate. Iodination of ^14^C‐dCTP was achieved with a radiochemical yield of 80%. Separation and purification of the reaction product were accomplished by reversed‐phase high performance liquid chromatography (RP‐HPLC).

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