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Synthesis and properties of polysaccharide prodrugs of 5-aminosalicylic acid as potential colon-specific delivery systems

โœ Scribed by Meijuan Zou; Hirokazu Okamoto; Gang Cheng; Xiuhua Hao; Jin Sun; Fude Cui; Kazumi Danjo

Book ID
116437298
Publisher
Elsevier Science
Year
2005
Tongue
French
Weight
200 KB
Volume
59
Category
Article
ISSN
0939-6411

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โœ Yun Jin Jung; Jeoung Soo Lee; Young Mi Kim ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 159 KB ๐Ÿ‘ 1 views

5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti