Synthesis and properties of dextran-5-aminosalicylic acid ester as a potential colon-specific prodrug of 5-aminosalicylic acid
โ Scribed by Yun Jin Jung; Jeoung Soo Lee; Hak Hyun Kim; Yun Taek Kim; Young Mi Kim
- Book ID
- 105671677
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 750 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0253-6269
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๐ SIMILAR VOLUMES
5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti
To evaluate N,N 0 -bis(5-aminosalicyl)-L-cystine (5-ASA-Cys) as a potential colon-specific 5-aminosalicylic acid prodrug with dual therapeutic effects in experimental colitis, the pharmacokinetics and therapeutic activity were investigated after oral administration of 5-ASA-Cys and amelioration of e