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Synthesis and anti-inflammatory testing of some new compounds incorporating 5-aminosalicylic acid (5-ASA) as potential prodrugs

✍ Scribed by Abdel-Alim Mohamed Abdel-Alim; Abdel-Nasser Ahmed El-Shorbagi; Samia Galal Abdel-Moty; Hajjaj Hassan Mohamed Abdel-Allah

Book ID
105671061
Publisher
Springer
Year
2005
Tongue
English
Weight
911 KB
Volume
28
Category
Article
ISSN
0253-6269

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In this study, we have explored the prevention of gastric side effects such as gastric lesions and bleeding while maintaining the high analgesic and anti-inflammatory activities by the derivatization of the carboxylate moiety into amides in [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl