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Synthesis and properties of 5-aminosalicyl-taurine as a colonspecific prodrug of 5-aminosalicylic acid

โœ Scribed by Yun Jin Jung; Hak Hyun Kim; Hye Sik Kong; Young Mi Kim

Book ID
105672767
Publisher
Springer
Year
2003
Tongue
English
Weight
518 KB
Volume
26
Category
Article
ISSN
0253-6269

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Colon-specific prodrugs of 5-aminosalicy
Colon-specific prodrugs of 5-aminosalicylic acid: Synthesis and in vitro/in vivo properties of acidic amino acid derivatives of 5-aminosalicylic acid
โœ Yun Jin Jung; Jeoung Soo Lee; Young Mi Kim ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 159 KB ๐Ÿ‘ 1 views

5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti