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Synthesis and properties of oligonucleotides containing the mutagenic base O4-benzylthymidine

✍ Scribed by Carme Fabrega; Ramon Eritja; Nanda D. Sinha; Manjit K. Dosanjh; Bea Singer

Book ID
103992033
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
659 KB
Volume
3
Category
Article
ISSN
0968-0896

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✦ Synopsis

The preparation of synthetic oligodeoxynucleotides containing O4-benzylthymidine (Tbn) is described. The use of standard and t-butylphenoxyacetyl amino protecting groups is compared. The thermal stabilities of duplexes containing Tbn paired with adenine and guanine have been measured.

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