Synthesis and triplex-forming properties of oligonucleotides containing thio-substituted C-nucleoside 4-thiopseudoisocytidine
โ Scribed by Shi-Qi Cao; Itaru Okamoto; Hirosuke Tsunoda; Akihiro Ohkubo; Kohji Seio; Mitsuo Sekine
- Book ID
- 104098623
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 434 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A 4-(3-n-butylureidophenyl)imidazole nucleoside was successfully incorporated into a triplex-forming oligonucleotide (TFO). Binding affinity and base pair selectivity of the TFO containing this non-natural nucleoside were studied with various duplex targets containing all four possible Watson-Crick
## Abstract Cyclohexyl nucleosides with an adenine and uracil base have been synthesized from 2โazidocyclohexaneโ1,5โdiol. The obtained racemic nucleosides were resolved using (__R__)โ__O__โmethylmandelic acid. Short oligonucleotides were synthesized using phorphoramidite chemistry. However, these
The synthesis of a new ribonucleoside analogue, which combines two modifications, namely a 2%-aminoethoxy side-chain on the ribose and a 5-methyl-1H-pyrimidin-2-one ( 4H T) unit as a base replacement, is presented. This building block was incorporated into triplex forming oligonucleotides and the bi