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Synthesis and properties of triplex-forming oligonucleotides containing 2′-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine

✍ Scribed by Chenguang Lou; Qiang Xiao; Lavinia Brennan; Mark E Light; Nuria Vergara-Irigaray; Elizabeth M. Atkinson; Lindy M. Holden-Dye; Keith R. Fox; Tom Brown


Book ID
108072892
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
768 KB
Volume
18
Category
Article
ISSN
0968-0896

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The synthesis of a new ribonucleoside analogue, which combines two modifications, namely a 2%-aminoethoxy side-chain on the ribose and a 5-methyl-1H-pyrimidin-2-one ( 4H T) unit as a base replacement, is presented. This building block was incorporated into triplex forming oligonucleotides and the bi