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Synthesis and structural and thermodynamic properties of oligonucleotides containing 2′-O-phosphorylated ribonucleosides

✍ Scribed by Hiroyuki Tsuruoka; Koh-ichiroh Shohda; Takeshi Wada; Mitsuo Sekine

Book ID
104255747
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
273 KB
Volume
37
Category
Article
ISSN
0040-4039

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✦ Synopsis

Conformation of the sugar, backbone and glycosidic bond of synthetic 2'-O-phosphorylated diuridylate U(2'-p)pU 1 was studied by NMR and CD. It was found that the 5' upstream ribose has predominantly an S-type of conformation. Tridecadeoxyuridylates incorporating a 2'-O-phosphorylated uridine U(2'-p) at the 3rd or 7th position were prepared by use of the polymer support synthesis and the effect of the 2'-O-phosphoryl group on the stability of the DNA duplex with dAi3 was examined. Both Tin experiments of these DNA duplexes and MD simulations of a duplex of dU3U(2'-p)dU3/dA7 suggested U(2'-p) has an extremely rigid S-type conformation when incorporaWal into the DNA duplex.

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