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Synthesis and pharmacokinetic profile of 3-methoxymethyl cephalosporin prodrugs

โœ Scribed by Myung Hee Jung; Kui-Woong Cho; Jewn-Giew Park; Young Hee Kim


Book ID
105672308
Publisher
Springer
Year
1998
Tongue
English
Weight
500 KB
Volume
21
Category
Article
ISSN
0253-6269

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Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters