Naltrexone-3-salicylate (a Prodrug of Naltrexone): Synthesis and Pharmacokinetics in Dogs
โ Scribed by Munir A. Hussain; Eli Shefter
- Book ID
- 114421075
- Publisher
- Springer US
- Year
- 1988
- Tongue
- English
- Weight
- 408 KB
- Volume
- 05
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The purpose of this study was to compare the percutaneous absorption and bioconversion of naltrexone (NTX), naltrexone-3-O-valerate (VAL), and naltrexone-3-O-(2 0 -ethylbutyrate) (ETBUT) in a human skin equivalent model (EpiDerm TM ) and in fresh human skin in vitro. NTX diffusion and metabolism to
Pharmacokinetic compartment models were constructed to describe the absorption and metabolism of dopamine (DA) and DA prodrug, N-(N-acetyl-L-methionyl)O,O-bis(ethoxycarbonyl) dopamine( 1). Plasma concentrations of DA, DA-SO,, and DOPAC after oral administration of DA to dogs, were analysed using the