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Physicochemical Evaluation,in VitroHuman Skin Diffusion, and Concurrent Biotransformation of 3-O-Alkyl Carbonate Prodrugs of Naltrexone

โœ Scribed by Omathanu Pillai; Mohamed O. Hamad; Peter A. Crooks; Audra L. Stinchcomb


Book ID
111603635
Publisher
Springer US
Year
2004
Tongue
English
Weight
185 KB
Volume
21
Category
Article
ISSN
0724-8741

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The purpose of this study was to compare the percutaneous absorption and bioconversion of naltrexone (NTX), naltrexone-3-O-valerate (VAL), and naltrexone-3-O-(2 0 -ethylbutyrate) (ETBUT) in a human skin equivalent model (EpiDerm TM ) and in fresh human skin in vitro. NTX diffusion and metabolism to