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Improvement of the oral bioavailability of naltrexone in dogs: A prodrug approach

โœ Scribed by Munir A. Hussain; Christopher A. Koval; Melvyn J. Myers; Elie G. Shami; Eli Shefter

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
325 KB
Volume
76
Category
Article
ISSN
0022-3549

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Several potential mechanisms for reduced levodopa bioavailability following oral administration to dogs and humans were investigated by studying the influence of the administration route on plasma levodopa levels after intravenous, hepatoportal, and duodenal administrations to dogs. The observed ave