Atypical dose–route-dependent food effec
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Chyung S. Cook; Liming Zhang
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Article
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2002
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John Wiley and Sons
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English
⚖ 157 KB
This study was conducted to investigate why a food effect was observed following an intravenous dose of eplerenone (EP) in the dog, but not following oral dosing. Three female dogs were implanted with a chronic portal vein access port and received radiolabeled EP doses orally (15 mg/kg in solution)