Galactosyl Prodrug of Ketorolac: Synthesis, Stability, and Pharmacological and Pharmacokinetic Evaluations
โ Scribed by Curcio, Annalisa; Sasso, Oscar; Melisi, Daniela; Nieddu, Maria; La Rana, Giovanna; Russo, Roberto; Gavini, Elisabetta; Boatto, Gianpiero; Abignente, Enrico; Calignano, Antonio; Rimoli, Maria Grazia
- Book ID
- 118180096
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 262 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Alkyl esters of ketorolac were synthesized as potential prodrugs for transdermal delivery and evaluated to determine the relationship between their skin permeation characteristics and their physicochemical properties. Solubility of the prodrugs in various vehicles was determined at room temperature
Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters