๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug

โœ Scribed by Yuqiang Wang; Huiling Yuan; Susan C Wright; Hong Wang; James W Larrick

Book ID
104497699
Publisher
BioMed Central
Year
2001
Tongue
English
Weight
541 KB
Volume
1
Category
Article
ISSN
1472-6769

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis and cytotoxicity of a biotinyl
Synthesis and cytotoxicity of a biotinylated CC-1065 analogue
โœ Yuqiang Wang; Huiling Yuan; Susan C Wright; Hong Wang; James W Larrick ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› BioMed Central ๐ŸŒ English โš– 200 KB

Background: The use of pretargeting technology for cancer imaging and treatment has made significant progress in the last few years. This approach takes advantage of the fact that biotin binds strongly to proteins avidin and streptavidin. Thus, a non-toxic tumor cell specific antibody is conjugated

Synthesis and Biological Evaluation of N
Synthesis and Biological Evaluation of Novel Analogues and Prodrugs of the Cytotoxic Antibiotic CC-1065 for Selective Cancer Therapy
โœ Lutzย F. Tietze; Tobias Herzig; Tim Feuerstein; Ingrid Schuberth ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 226 KB ๐Ÿ‘ 2 views

This paper describes novel seco-analogues 25-27 of the cytotoxic antibiotic CC-1065 (1) and their prodrugs 5, 6a, and 6b, for antibody-directed enzyme prodrug therapy (ADEPT). The partially hydrogenated seco-CCI-analogue 7 and the corresponding methyl-CCI analogues 8a and 8b were synthesized by alky