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Synthesis and Preliminary Biological Evaluations of CC-1065 Analogues: Effects of Different Linkers and Terminal Amides on Biological Activity

โœ Scribed by Wang, Yuqiang; Yuan, Huiling; Ye, Wenqing; Wright, Susan C.; Wang, Hong; Larrick, James W.


Book ID
126947844
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
274 KB
Volume
43
Category
Article
ISSN
0022-2623

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โœ Lutzย F. Tietze; Tobias Herzig; Tim Feuerstein; Ingrid Schuberth ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 226 KB ๐Ÿ‘ 2 views

This paper describes novel seco-analogues 25-27 of the cytotoxic antibiotic CC-1065 (1) and their prodrugs 5, 6a, and 6b, for antibody-directed enzyme prodrug therapy (ADEPT). The partially hydrogenated seco-CCI-analogue 7 and the corresponding methyl-CCI analogues 8a and 8b were synthesized by alky