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Selective Treatment of Cancer: Synthesis, Biological Evaluation and Structural Elucidation of Novel Analogues of the Antibiotic CC-1065 and the Duocarmycins

✍ Scribed by Lutz F. Tietze; Felix Major; Ingrid Schuberth; Dirk A. Spiegl; Birgit Krewer; Katja Maksimenka; Gerhard Bringmann; Jörg Magull


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
565 KB
Volume
13
Category
Article
ISSN
0947-6539

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✍ Lutz F. Tietze; Tobias Herzig; Tim Feuerstein; Ingrid Schuberth 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB 👁 2 views

This paper describes novel seco-analogues 25-27 of the cytotoxic antibiotic CC-1065 (1) and their prodrugs 5, 6a, and 6b, for antibody-directed enzyme prodrug therapy (ADEPT). The partially hydrogenated seco-CCI-analogue 7 and the corresponding methyl-CCI analogues 8a and 8b were synthesized by alky