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Synthesis and Opioid Activity of Enantiomeric N -Substituted 2,3,4,4a,5,6,7,7a-Octahydro-1 H -benzofuro[3,2- e ]isoquinolines

✍ Scribed by Hsin, Ling-Wei; Chang, Li-Te; Rothman, Richard B.; Dersch, Christina M.; Fishback, James A.; Matsumoto, Rae R.


Book ID
120420770
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
849 KB
Volume
53
Category
Article
ISSN
0022-2623

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Synthesis of 3-methyl-2,3,4,4a,5,6-hexah
✍ Dwight D. Weller; Doreen L. Weller πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 219 KB

The 2,3,4,4a,5, isoquinoline-7(7aH)-one ring system is prepared from a 4-arylpyridine precursor by sequential intramolecular enolate addition to a pyridinium ion, Dieckmann cyclization, and catalytic hydrogenation.