Synthesis and Opioid Activity of 7-Oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolinols
β Scribed by Cheng, Chen-Yu; Hsin, Ling-Wei; Tsai, Ming-Cheng; Schmidt, William K.; Smith, Christine; Tam, S. William
- Book ID
- 126505917
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 922 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
The 2,3,4,4a,5, isoquinoline-7(7aH)-one ring system is prepared from a 4-arylpyridine precursor by sequential intramolecular enolate addition to a pyridinium ion, Dieckmann cyclization, and catalytic hydrogenation.
The title compound, C~22~H~29~NO~4~S, crystallizes with three independent molecules, __A__, __B__ and __C__, in the asymmetric unit. Each of the three independent molecules adopts a folded conformation, with the phenylsulfonyl group lying over the pyranocyclohexanone ring system, and with the pyrrol