Synthesis of morphine fragments spiro[be
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Chen-Yu Cheng; Jing-Ping Liou; Mei-Jing Lee
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Article
📅
1997
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Elsevier Science
🌐
French
⚖ 209 KB
As a better alternative to radical cyclization, 5-(2-bromo-6-methoxyphenoxy)-2-methyl-l,2,3,4,5,6,7,8-octahydroisoquinoline (2) and its 1-oxo analog 3 underwent Pdcatalyzed intramolecular cyclization to give the tetracyclic (ACNO) morphine fragments 5 and 6 respectively. 4-[(2'-Iodo-6'-methoxyphenox