## Abstract Owing to the ozone layerβdepleting properties of chlorofluorocarbon compounds, alternative solvents for electrophilic fluorination reactions are desirable. Chloroform, dichloromethane, acetone or their deuterated analogues were examined as substitutes for Freonβ11 in the electrophilic s
Synthesis and HPLC Separation of 6-Fluoro-L-Dopa Metabolites
β Scribed by A. Luxen; M. Monclus; P.-Y. Hendrickx; C. Masson; W. P. Melega
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 519 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0037-9646
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Previous work from this laboratory has shown that the direct fluorination of 3, 4-dihydroxy-phenyl-lalanine (l-DOPA) in anhydrous HF (aHF) or BF 3 /HF with F 2 is an efficient method for the synthesis of 6-fluoro-l-DOPA. Since then, 18 F-labeled 6-fluoro-l-DOPA ([ 18 F]6-fluoro-l-DOPA) has been used
## Abstract Progression of Parkinson's disease symptoms is imperfectly correlated with positron emission tomography biomarkers for dopamine biosynthetic pathways. The radiopharmaceutical 6β[^18^F]fluoroβmβtyrosine is not a substrate for catecholβ__O__βmethyltransferase and therefore has a more favo