𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nucleophilic enantioselective synthesis of 6-[18F]Fluoro-l-dopa via two chiral auxiliaries

✍ Scribed by Christian Lemaire; Alain Plenevaux; Robert Cantineau; Leon Christiaens; Marcel Guillaume; Dominique Comar

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
832 KB
Volume
44
Category
Article
ISSN
0969-8043

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Alternative solvents for electrophilic s
Alternative solvents for electrophilic synthesis of 6-[18F]fluoro-L-DOPA
✍ Sarita Forsback; Olli Eskola; JΓΆrgen Bergman; Merja Haaparanta; Olof Solin πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 French βš– 95 KB πŸ‘ 1 views

## Abstract Owing to the ozone layer‐depleting properties of chlorofluorocarbon compounds, alternative solvents for electrophilic fluorination reactions are desirable. Chloroform, dichloromethane, acetone or their deuterated analogues were examined as substitutes for Freon‐11 in the electrophilic s

Enantioselective synthesis via the nucle
Enantioselective synthesis via the nucleophilic alkylation of hydrazones: Acetals as chiral auxiliaries.
✍ Mohamadou Thiam; Francine Chastrette πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 French βš– 231 KB

Oiastereoselective addition of organolithium reagents on hydrazones vicinal to chiral cyclic acetals provide chiral hydrazinoacetals from which optically active aminoacetals and aminoacids can be prepared. Recently the syntheses of optically active amines involving the addition of organometallic rea

Synthesis of 6-[18F] and 4-[18F]fluoro-l
Synthesis of 6-[18F] and 4-[18F]fluoro-l-m-tyrosines via regioselective radiofluorodestannylation
✍ Mohammad Namavari; N. Satyamurthy; Michael E. Phelps; Jorge R. Barrio πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 960 KB

The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-m-tyrosine derivative 6 with [18F]F2 and [18F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[18F]fluoro-L-m-tyrosine (8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[18F]fluoro-L-m-tyrosine (13a) was

Regioselective radiofluorodestannylation
Regioselective radiofluorodestannylation with [18F]F2 and [18F]CH3COOF: A high yield synthesis of 6-[18F]fluoro-l-dopa
✍ Mohammad Namavari; Allyson Bishop; N. Satyamurthy; Gerald Bida; Jorge R. Barrio πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science βš– 975 KB

A protected 6-trimethylstannyl dopa derivative 6 has been synthesized for the first time as a precursor for the preparation of 6-[18F]fluoro-L-dopa. The tin derivative 6 readily reacted with electrophilic radiofluorinating agents such as [18F]F2 and [18F]AcOF. The [18F]fluoro intermediate 7 was easi