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Synthesis and histamine H1-receptor antagonist activity of 4-(diphenylmethyl)-1-piperazine derivatives with a terminal heteroaryl or cycloalkyl amide fragment

✍ Scribed by A Orjales; JC Gil-Sánchez; L Alonso-Cires; L Labeaga; R Mosquera; A Berisa; M Ucelay; A Innerárity; R Corcóstegui

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
617 KB
Volume
31
Category
Article
ISSN
0223-5234

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✍ A. ORJALES; J. C. GIL-SANCHEZ; L. ALONSO-CIRES; L. LABEAGA; R. MOSQUERA; A. BERI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

Synthesis and Histamine H1-Receptor Antagonist Activity of 4-( Diphenylmethyl)-1-piperazine Derivatives with a Terminal Heteroaryl or Cycloalkyl Amide Fragment. -The title compounds (I) have the highest biological activities and are as potent in vivo as cetirizine.