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Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion

โœ Scribed by Mr. David L. Musso; Nariman B. Mehta; Francis E. Soroko; Robert M. Ferris; Elizabeth B. Hollingsworth; Bernard T. Kenney

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
529 KB
Volume
5
Category
Article
ISSN
0899-0042

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โœฆ Synopsis

The synthesis of the enantiomers of bupropion, (ruc)-2-tevt-butylamino-3'chloropropiophenone 1 (Wellbutrin@) is described. The enantiomers were compared with the racemate in both the tetrabenazine-induced sedation model and the inhibition of uptake of biogenic amine assay. No significant differences were found in their potencies to reverse tetrabenazine-induced sedation in mice or in their IC,, values as inhibitors of biogenic amine uptake into nerve endings obtained from mouse brain. o 1993 Wiey-Liss, Inc.

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