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Synthesis and evaluation of the anticonvulsant activity of a series of 2-amino-1-phenyl-1-propanols derived from the metabolites of the antidepressant bupropion

✍ Scribed by David L. Musso; Nariman B. Mehta; Francis E. Soroko

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 229 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00577-x

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✦ Synopsis

A series of 2-amino-l-phenyl-l-propanols that are structurally related to known metabolites of bupropion,1 (Wellbutrin®) were synthesized and evaluated as potential anticonvulsants. The (R*,R*)-2tert-butylamino-l-(3-trifluoromethylphenyl) propanol 20 had an EDs0 of 16.5 + 2.8 mg/kg ip in mice in the maximal electroshock screen and was chosen for further evaluation.

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