✦ LIBER ✦

Estimating the lipophilicity of a number of 2-amino-1-cyclohexanol derivatives exhibiting anticonvulsant activity

✍ Scribed by Elżbieta Pękala; Henryk Marona

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 134 KB
Volume: 23
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.1153

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The lipophilicity of a number of N‐acyl derivatives of trans‐ or cis‐: racemic, (1__R__,2__R__)‐ or (1__S__,2__S__)‐aminocyclohexanol (1–13) exhibiting anticonvulsant activity was investigated. Their lipophilicity (R~m0~) was determined using reversed‐phase thin‐layer chromatography (RP‐TLC) with mixtures of methanol and water as mobile phases. The partition coefficients of compounds 1–13 (log P) were also calculated using two computer programs (Pallas and Chem DU) and compared with R~m0~. Copyright © 2009 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Estimation of the lipophilicity of antia

Estimation of the lipophilicity of antiarrhythmic and antihypertensive active 1-substituted pyrrolidin-2-one and pyrrolidine derivatives

✍ Katarzyna Kulig; Barbara Malawska 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 2 views

A Highly Stereoselective Synthesis of Op

A Highly Stereoselective Synthesis of Optically Active Trisubstituted 1,2-Ethylenediamines: The First Example of Grignard Addition to N-Diphenylphosphinoyl Ketimines Derived from Amino Acids.

✍ Yoshinori Kohmura; Toshiaki Mase 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 262 KB 👁 1 views

ChemInform Abstract: Synthesis of a Simp

ChemInform Abstract: Synthesis of a Simplified Version of Stable Bulky and Rigid Cyclic (Alkyl)(amino)carbenes, and Catalytic Activity of the Ensuing Gold(I) Complex in the Three-Component Preparation of 1,2-Dihydroquinoline Derivatives.

✍ Xiaoming Zeng; Guido D. Frey; Rei Kinjo; Bruno Donnadieu; Guy Bertrand 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 47 KB 👁 1 views